荷葉堿
分析標(biāo)準(zhǔn)品,HPLC≥98%
Nuciferine
CAS號(hào)：475-83-2
分子式：C19H21NO2
分子量：295.376
MDL：MFCD01664592
貨號(hào) | 規(guī)格/參數(shù)/品牌 | 價(jià)格 | 貨期 |
YJ-B20500-20mg | 分析標(biāo)準(zhǔn)品,HPLC≥98% | ￥600.00 | 現(xiàn)貨 |
YJ-B20500-200mg | 分析標(biāo)準(zhǔn)品,HPLC≥98% | ￥2500.00 | 現(xiàn)貨 |
JS27992-1g | 90% | ￥950.00 | 現(xiàn)貨 |
JS27992-5g | 90% | ￥2780.00 | 現(xiàn)貨 |
A10254-20mg | 分析標(biāo)準(zhǔn)品,含量91.3%，可溯源 | ￥1300.00 | 現(xiàn)貨 |
產(chǎn)品介紹
藥理藥效：具有減肥降脂的作用。
熔點(diǎn)：165.5℃
沸點(diǎn)：430.7℃at760mmHg
比旋光度：(c, 1 in EtOH)-164
外觀：白色粉末
溶解性：DMSO：3mg/ml
儲(chǔ)存條件：2-8℃
注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。
參考文獻(xiàn)(45篇)
45. [IF=4.9] Lalai Zikela et al."Effects and Mechanisms of Nuciferine on Constipation through Regulation of the SCF/c-Kit/NF-κB/TLR4 Signaling Pathway in STC Model Mice."JOURNAL OF NUTRITIONAL BIOCHEMISTRY.2025 Jul;:110045
44. [IF=6.3] Shengnan Zhu et al."Nuciferine Exerts Anti-Inflammatory Effects in Mice With Non-Alcoholic Steatohepatitis by Regulating the miR-23a-3p-SIRT1-NF-κB Pathway and Akkermansia muciniphila-Extracellular Vesicles."PHYTOTHERAPY RESEARCH.2025 Jul;:
43. [IF=3.5] Zhiqiang Zhao et al."Nuciferine alleviates non-alcoholic steatohepatitis by restoring endoplasmic reticulum stress."EXPERIMENTAL CELL RESEARCH.2025 Jun;449:114599
42. [IF=5.7] Sha Chen et al."Characterization and Molecular Engineering of a N-Methyltransferase from Edible Nelumbo nucifera Leaves Involved in Nuciferine Biosynthesis."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2024;72(41):22926–22938
41. [IF=2.8] Kun Yang et al."Rutin Ameliorates BHBA-Induced Inflammation and Lipid Accumulation in Calf Hepatocytes Through NF-κB Signaling Pathway."CURRENT ISSUES IN MOLECULAR BIOLOGY.2025 Apr;47(4):274
40. [IF=4.6] Hao WANG et al."Nuciferine alleviates collagen-induced arthritic in rats by inhibiting the proliferation and invasion of human arthritis-derived fibroblast-like synoviocytes and rectifying Th17/Treg imbalance."Chinese Journal of Natural Medicines".2024 Ap
39. [IF=9.9] Xiangyang Zhu et al."Neuroprotective effects of nuciferine on high-fat diet-induced cognitive dysfunction in obese mice: Role of insulin resistance, neuroinflammation, and oxidative stress."Food Frontiers".2024 Feb;:
38. [IF=8.4] Yanzhao Liu et al."Enzyme-Assisted Extraction of Nuciferine and Quercetin from Lotus Leaves Using the Aqueous-Based Method: A Sustainable Approach."ACS Sustainable Chemistry & Engineering.2023;11(50):17687–17696
37. [IF=6] Jiahuan Xu et al."A new strategy for the preparation of nuciferine from lotus leaf via expanded bed adsorption extraction integrated with pH dependent liquid-liquid extraction and cooling crystallization."Sustainable Chemistry and Pharmacy.2024 Feb;37:1014
36. [IF=3.5] Zhiyuan Fang et al."Nuciferine protects bovine hepatocytes against free fatty acid-induced oxidative damage by activating the transcription factor EB/peroxisome proliferator-activated receptor γ coactivator 1 alpha pathway."JOURNAL OF DAIRY SCIENCE.10.3168
35. [IF=5.464] Jiahuan Xu et al."D-limonene as an alternative for the extraction and purification of nuciferine from lotus leaf via multi-stage vortex assisted two-phase solvent extraction integrated with solid phase extraction using mesoporous material SBA-15 as adsorb
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33. [IF=5.895] Jinxia Li et al."Nuciferine Ameliorates Nonesterified Fatty Acid-Induced Bovine Mammary Epithelial Cell Lipid Accumulation, Apoptosis, and Impaired Migration via Activating LKB1/AMPK Signaling Pathway."JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY.2022;XXXX(
32. [IF=7.291] Yu Yuetong et al."Functional characterization and key residues engineering of a regio-promiscuity O-methyltransferases involved in benzylisoquinoline alkaloid biosynthesis in Nelumbo nucifera."Horticulture Research.2022 Dec;:
31. [IF=3.2] Chenyang Hao et al."Nontarget Metabolites of Rhizomes of Edible Sacred Lotus Provide New Insights into Rhizome Browning."JOURNAL OF FOOD QUALITY.2022 Oct 26;2022:3943052
30. [IF=0] Danni Wang et al."Identification of Q-Markers from Hedan Tablet by employing “spider-web" mode and taking compounds’ hepatotoxicity into account."Chinese Herbal Medicines.2022 Aug;:
29. [IF=4.212] Chang Chen et al."Nuciferine attenuates acute ischemic stroke in a rat model: a metabolomic approach for the mechanistic study."Molecular Omics.2022 Jul;:
28. [IF=5.307] Yu-kai Zhang et al."Synthesis and bioactivity evaluation of novel nuciferine derivatives with antihyperuricemia and nephroprotective effects."BIOORGANIC CHEMISTRY.2022 Sep;126:105916
27. [IF=7.491] Yeqing Ruan et al."Processing tactics for low-cost production of pure nuciferine from lotus leaf."ULTRASONICS SONOCHEMISTRY. 2022 May;86:106026
26. [IF=3.394] Chang Chen et al."Protective Effects of Nuciferine in Middle Cerebral Artery Occlusion Rats Based on Transcriptomics."Brain Sciences. 2022 May;12(5):572
25. [IF=11.413] Xiliang Du et al."Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy–lysosomal pathway."Acta Pharm Sin B. 2021 Dec;:
24. [IF=1.902] Yongjing Liu et al."Evaluation of Green and Efficient deep eutectic solvents as media for extracting Alkaloids from Lotus Leaf."Biomedical Chromatography. 2021 Dec 06
23. [IF=7.514] YueTong Yu et al."Identification and Quantification of Oligomeric Proanthocyanidins, Alkaloids, and Flavonoids in Lotus Seeds: A Potentially Rich Source of Bioactive Compounds."Food Chem. 2022 Jan;:132124
22. [IF=3.373] Na Zhang et al."TLC–MS identification of alkaloids in Leonuri Herba and Leonuri Fructus aided by a newly developed universal derivatisation reagent optimised by the response surface method."Phytochem Analysis. 2021 May;32(3):242-251
21. [IF=3.935] Peiliang Zhang et al."TLC-electrostatic field induced spray ionization-MS analysis of diverse structural skeletons and its coupling with TLC bioautography for characterization of lipase inhibitory components in American ginseng."J Pharmaceut Biomed. 2019
20. [IF=4.451] Haiyan Wen et al."Nuciferine attenuates the progression of osteoarthritis by targeting PI3K/Akt/NF-κB signaling pathway."J Funct Foods. 2021 Nov;86:104682
19. [IF=5.396] Zhen Shi et al."Nuciferine improves high-fat diet-induced obesity via reducing intestinal permeability by increasing autophagy and remodeling the gut microbiota."Food Funct. 2021 Jul;12(13):5850-5861
18. [IF=3] Zhang Pengyu et al."Discovery of novel antagonists on β2-adrenoceptor from natural products using a label-free cell phenotypic assay."N-S Arch Pharmacol. 2018 Dec;391(12):1411-1420
17. [IF=3.174] Chen Xingxing et al."Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway."Inflamm Res. 2018 Dec;67(11):903-911
16. [IF=3.225] Fugang Wang et al."Pharmacokinetics, tissue distribution, bioavailability, and excretion of nuciferine, an alkaloid from lotus, in rats by LC/MS/MS."Drug Dev Ind Pharm. 2018;44(9):1557-1562
15. [IF=3.512] Thitirat Meelaph et al."Coregulation of Biosynthetic Genes and Transcription Factors for Aporphine-Type Alkaloid Production in Wounded Lotus Provides Insight into the Biosynthetic Pathway of Nuciferine."Acs Omega. 2018;3(8):8794–8802
14. [IF=5.279] Xianbao Deng et al."Analysis of Isoquinoline Alkaloid Composition and Wound-Induced Variation in Nelumbo Using HPLC-MS/MS."J Agr Food Chem. 2016;64(5):1130–1136
13. [IF=6.558] Lei Zhang et al."Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves."Anal Chim Acta. 2017 May;967:52
12. Zhang, Lei, et al. "Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves." Analytica chimica acta 967 (2017): 5
11. Zhang, Lei, et al. "Direct coupling of thin-layer chromatography-bioautography with electrostatic field induced spray ionization-mass spectrometry for separation and identification of lipase inhibitors in lotus leaves." Analytica chimica acta 967 (2017): 5
10. Chen, X., Zheng, X., Zhang, M. et al. Nuciferine alleviates LPS-induced mastitis in mice via suppressing the TLR4-NF-κB signaling pathway. Inflamm. Res. 67, 903–911 (2018). https:##doi.org/10.1007/s00011-018-1183-2
9. Fugang Wang, Juan Cao, Xueqin Hou, Zhiyong Li & Xiaolan Qu (2018) Pharmacokinetics, tissue distribution, bioavailability, and excretion of nuciferine, an alkaloid from lotus, in rats by LC/MS/MS, Drug Development and Industrial Pharmacy, 44:9, 1557-1562, D
8. 鄭艷艷,李莉,袁曉慶,孔方,劉言娟.響應(yīng)面法優(yōu)化蝸牛酶輔助超聲提取荷葉總生物堿的工藝研究[J].安徽農(nóng)業(yè)科學(xué),2020,48(21):183-187.
7. 陳強(qiáng),張華,沙玫,劉永靜.一測(cè)多評(píng)法同時(shí)測(cè)定荷葉中4種生物堿含量[J].福建中醫(yī)藥,2020,51(06):29-32.
6. 尹秀文, 侯成波, 陳江鵬,等. 采用在體單向腸灌流模型研究荷葉多成分整體的腸滲透性[J]. 中國中藥雜志, 2017, 42(008):1525-1531.
5. 李帆. 荷葉堿在青霉菌培養(yǎng)基中抑菌效果的研究[J]. 生物化工, 2018, 4(06):99-101.
4. 侯成波, 董月柳, 尹秀文,等. 荷葉多成分整體的腸滲透性研究[J]. 中國中藥雜志, 2016, 41(07):1183-1187.
3. 吳鵬,李慧芬,張學(xué)蘭,崔偉亮,王均秀.炒炭對(duì)荷葉主要化學(xué)成分轉(zhuǎn)化機(jī)制的研究[J].中成藥,2015,37(08):1767-1770.
2. 李夢(mèng)杰 劉蘇珍 周斌 等. RP-HPLC法同時(shí)測(cè)定荷葉顆粒中3種有效成分的含量[J]. 中國藥房 2016(18期):2532-2534.
1. 夢(mèng)杰 劉蘇珍 周斌 崔小弟 陳振華.HPLC法同時(shí)測(cè)定荷葉中的荷葉堿、蘆丁、槲皮素[J].中成藥 2016 38(01):111-114.
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